Therapy of Heart Diseases with Stem Cell Therapy in Turkey

Other than stem cell therapy, there is no therapy strategy that directly strengthens the heart muscle. 87% of patients getting stem cell therapy for heart failure and ischemic heart disease improved at various degrees.

●    Stem cells can repair ill veins by touching the sick vein wall, and they can also treat heart failure by transforming into heart muscle cells if the heart muscles are weak.

●    The amount of cells to be supplied is decided by the patient's age and weight.

●    Endothelial, mesenchymal (produced from the patient's own adipose tissue or bone marrow), or fetal stem cells are used in therapy.

●    ​​​​​​​The patient is given stem cells intravenously.

What are Heart Failure and Ischemic Heart Diseases?

Ischemic Heart Diseases

Cells require blood flow to survive and operate. This blood flow transports oxygen and nutrients to the tissues while also removing waste. Ischemia is defined as a lack of sufficient blood flow to support cell processes. In a nutshell, it's a reduction in blood flow. Ischemic heart disorders are caused by a failure to nourish the heart muscle for a variety of causes.

Heart Failure

Heart failure is a dangerous ailment characterized by fluid buildup in the lungs and other regions of the body as a result of the heart's inability to pump enough blood to fulfill the body's demands. Conditions such as cardiovascular disease (for example, suffering a heart attack), high blood pressure, heart valve disease, heart muscle disease or inflammation, and congenital heart disease all raise the chance of developing heart failure.

What are the Symptoms of Heart Failure and Ischemic Heart Diseases?

●    ​​​​​​​Breathing difficulty

●    ​​​​​​​When breathing, you may hear a coughing or whistling sound.

●    ​​​​​​​Weight gain or loss

●    ​​​​​​​Swelling of the ankles

●    ​​​​​​​Lack of Appetite

●    ​​​​​​​The requirement to urinate at night

●    ​​​​​​​Tiredness/fatigue

●    ​​​​​​​Dizziness/drowsiness

●    ​​​​​​​Heart rate increase

●    ​​​​​​​Anxiety and Depression

Causes of Ischemic Heart Disease

The most prevalent cause is atherosclerosis-related occlusion or constriction of the coronary veins supplying the heart, often known as vascular stiffness among the general population. As a result of this blockage or constriction, the heart cannot get the oxygen and nutrients it requires, and its normal functioning is compromised, resulting in a variety of complaints and symptoms.

Atherosclerosis, or vascular stiffness, is the most common cause of total or diminished blood flow. Many variables, including excessive cholesterol, high blood pressure, and smoking, cause plaques to develop in the vessel wall over time, resulting in vascular flexibility loss.

These plaques accumulate over time, constricting the vein and even preventing proper blood flow (chronic). Or the plaques break rapidly and totally obstruct the vein (acute).

Ischemia can also occur as a result of embolism, blood vessel twisting, or compression. Ischemia can also occur as a result of aberrant blood vessel contraction in the absence of an occlusive mechanical cause.

Ischemic Heart Disease Therapy Methods

Therapy for heart disease relies on the kind and extent of the condition. Acute diseases, such as heart attacks, need prompt medical attention to reduce cardiac damage. For chronic conditions, doctors may advise patients to change their diet, decrease weight, exercise (supervised), practice stress management, and stop smoking. Both diabetes and hypertension should be managed to reduce the detrimental consequences on the heart. Heart failure is frequently treated with a low-salt diet, drugs that increase heart muscle function, such as digoxin, and diuretics to lower the amount of accumulated fluid.

To assist manage cardiac disease and treat new issues, medications may be required. Surgical therapys may be required to clear clogged arteries, replace faulty heart valves, or fix congenital defects. Those who have been infected may require antibiotics.

Heart Failure Therapy

Other than stem cell therapy, there is no method of therapy that directly strengthens the heart muscle.

Therapy of Heart Diseases with Stem Cells

When stem cells come into contact with a diseased vein, they have the power to heal it. They are also utilized to treat heart failure by transforming into heart muscle cells if the heart muscles are weak.

They hasten post-operative healing by strengthening the autoimmune system. They hasten the therapy of inflammation and cardiac muscle irritation.

Endothelial stem cells (used to treat veins) are employed to construct vessel walls. The majority of these stem cells are sourced from bone marrow. However, mesenchymal or fetal stem cells are employed in conjunction with other disease-causing components. The cardiac muscle, the systemic autoimmune system, and other components are addressed in this manner.

The amount of cells to be supplied is decided by the patient's age and weight. Endothelial, mesenchymal (produced from the patient's own adipose tissue or bone marrow), or fetal stem cells are used in therapy. The choice is based on the patient's condition. It is done in three 45-day periods or two consecutive days. They are given intravenously (through vascular access).

Various degrees of recovery were reported in 83% of individuals with cardiovascular disease.

FREQUENTLY ASKED QUESTIONS

How is ischemic heart disease and heart failure diagnosed?

Laboratory Tests

Biologic indicators unique to the heart are proteins that are generated when muscle cells are injured, and they are frequently tested in patients who have chest pain, chin, neck, abdomen, back discomfort or pain extending to the shoulder or arms, nausea, shortness of breath, or dizziness.

Tests:

●    ​​​​​​​Troponin - is one of the most analyzed heart-specific markers. It increases within a few hours after heart is damaged and remains in such levels for up to 2 weeks.

●    ​​​​​​​CK-MB - a special form of Creatine Kinase enzyme, which is mostly found in heart muscle. This enzyme increases when the heart muscle cells are damaged.

●    ​​​​​​​Myoglobin - is a protein that is released into the blood when the heart or other skeletal muscle is injured.

●    ​​​​​​​BNP or NT-proBNP - is released by the body as a natural response to heart failure. Increased BNP levels indicate an increased risk of cardiac problems in patients with acute coronary syndrome, although it is not a diagnostic tool for heart attack.

Since BNP is also released from the stretched heart, it is also measured to determine whether heart failure exists in patients who have swelling in their legs or abdomen or those suffering from shortness of breath.

More general blood tests may also be requested:

●    ​​​​​​​Blood Gases - analyzed to assess oxygen, carbon dioxide and pH levels.

●    ​​​​​​​Comprehensive Metabolic Panel (CMP) - a set of tests used to assess organic function

●    ​​​​​​​Electrolytes - four tests assessing the body's electrolyte balance

●    ​​​​​​​Complete blood count - examines body cells, checks for anemia.

Other assessments

To examine chest discomfort and other indicators of illness, a variety of assessments and tests are employed. Patient history, for example, in which risk factors such as age, coronary artery disease, diabetes, and smoking are assessed.

Physical examinations

●    ​​​​​​​Electrocardiogram (ECG) - examines the electrical activity and rhythm of the heart.

●    ​​​​​​​Echocardiography - ultrasonographic imaging of the heart.

Based on the findings of these tests, other procedures may also be necessary:

●    ​​​​​​​Stress Test

●    ​​​​​​​Chest X-ray

●    ​​​​​​​CT (computed tomography) screening

●    ​​​​​​​Continuous ECG monitoring (sometimes called Holter monitoring) - The patient wears a recorder that evaluates the heart rhythm for a certain period of time.

●    ​​​​​​​MRI (Magnetic Resonance Imaging)

●    ​​​​​​​PET (Positron emission tomography)

●    ​​​​​​​Radioisotope imaging

●    ​​​​​​​Cardiac catheterization - in this procedure, a thin flexible tube is inserted into a leg vein and advanced to the coronary arteries to assess intra-cardiac blood flow, pressure and condition of the arteries.

●    ​​​​​​​Coronary angiography - this is a method of imaging the arteries using a radiation-proof material during coronary catheterization to help diagnose coronary artery disease.

●    ​​​​​​​Tilt-table testing - it is requested for the evaluation of syncope.