Muscular Dystrophy (Myolysis) in Turkey

Myolysis progression can be delayed, reversed, or even prevented entirely using stem cell therapy. The success rate of the therapy is related to the patient's age, disease duration, and condition.

●    The use of stem cells to treat MYOLYSIS is acknowledged as a new strategy that scientists are working on.

●    Stem cells have the potential to transform into muscle cells when they come into contact with injured muscle cells, which is why they are employed to treat myolysis.

●    ​​​​​​​The amount of cells to be supplied is decided by the patient's age and weight. Mesenchymal stem cells (produced from the patient's own adipose tissue or bone marrow) or fetal stem cells are used in therapy. The choice is based on the patient's condition. It is done in three 45-day periods or three consecutive days.

●    ​​​​​​​A success rate of 88% was attained in areas such as overall improvement in quality of life of patients with varying degrees of illness, disease regression, and immune system strengthening.

What is Myolysis Disease?

The most prevalent muscular illness in males is Duchenne Muscular Dystrophy (DMD). A fundamental protein required for muscle function is absent in this condition. In the absence of this protein, the muscles eventually deteriorate and are replaced by adipose tissue.

Myolysis is caused by a malfunction in the gene that codes for the Dystrophin protein, which is a muscle protein, producing it at a slower rate than usual. Males have XY chromosomes, whereas females have XX chromosomes. Because the chromosome containing Dystrophin is the X chromosome, there is X-linked inheritance. Because guys have only one X chromosome, the sickness only affects men. It may arise in rare cases owing to mutations that occur when the kid is in the mother's womb.

Parents of certain children may detect swollen and rigid calf muscles and visit a doctor. It is a hereditary condition characterized by gradual skeletal muscle degeneration, resulting in muscular weakening and atrophy.

It begins with the area surrounding the shoulders, hip girdle, and thighs. The illness progresses slowly, and some people can occasionally walk into their 30s. The cardiac muscle is sometimes engaged as well.

What are the Symptoms of Myolysis?

●    ​​​​​​​It is characterized by excessive fatigue and difficulties doing tasks such as getting up from the floor, going uphill, and climbing stairs. It is commonly diagnosed between the ages of two and five. Some children lag behind their contemporaries at every stage of development after birth, while others develop qualities that are comparable to their peers.

●    ​​​​​​​During childhood, very minor symptoms are common. Learning to walk may be postponed. Muscular weakness, difficulties rising up, walking quickly and ascending stairs, frequent falls, waddling gait, muscle pains and cramps are all noted over time.

●    ​​​​​​​The muscles surrounding the hips and shoulders eventually weaken, and the abdominal and back muscles weaken as well, causing them to walk with their abdomens forward. As their leg muscles weaken, kids begin to fall frequently, have trouble getting up and mounting stairs, and begin to need wheelchairs between the ages of 9 and 11 when they lose their ability to walk. Following this stage, the arm muscles gradually weaken and the person has trouble utilizing his or her arms.

Causes of Myolysis

The sickness was passed down from generation to generation, or this gene was created wrongly while the infant was still in the mother's womb. In both circumstances, the outcome is the same. Myolysis is a congenital and hereditary disorder since the sick gene resides on the X chromosome, one of the gender chromosomes.

Each individual has 23 pairs of chromosomes, one from each parent. These chromosomes also include the genes that define our genetic structure. A person possessing a hereditary illness gene is more likely to have a close relative with the same disease gene than persons who are unrelated. This raises the likelihood of the infant inheriting the gene that wrongly encodes dystrophine. As a result, the illness affects children born as a result of consanguineous marriage twice as much as other newborns.

Therapy of Myolysis

There is currently no recognized medication therapy for this condition, and no medicine has been developed that can entirely remove the sickness. Methods that can replace or work as dystrophin in muscle cells are being researched in nations where research has been conducted on this issue.