Therapy of Oligospermia in Turkey (Low Sperm Count) with Stem Cells

Oligospermia can be treated with stem cell therapy, and patients who can not have children due to low sperm count are able to have children upon reaching the desired sperm quality and quantity after therapy. The success rate is 95% and above in patients who are eligible for therapy.

●    In Oligospermia, the stem cells provided to the patient transform into low-count sperm cells that can replicate.

●    Therapy for oligospermia using stem cells is available to all adult men who have sperm cells, even if they are in small amounts.

●    Stem cells isolated from the patient's adipose tissue rich in stem cells are multiplied in the laboratory and supplied to the patient through intravenous route and/or injection to the region as the physician deems suitable.

●    ​​​​​​​​​​​​​​It has been found that people who have been unable to have children for years due to low sperm count can have children after therapy.

What is Oligospermia (Low Sperm Count)?

Oligospermia occurs when the amount of sperm cells in an adult male's semen (liquid containing sperm) is fewer than 20 million/ml. Because the concentration of sperm in semen (liquid containing sperm) varies according to people's living situations, oligospermia is defined in current World Health Organization studies as sperm count fewer than 15 million.

What are the symptoms of Oligospermia (Low Sperm Count)?

If an adult man, despite his desire, is unable to have children and his partner is not having any difficulty, the male's sperm count is evaluated. There are no signs of sperm deficiency in the body.

Oligospermia (Low Sperm Count) Degrees

As the outcome of the study, mild oligospermia is identified when the sperm count is 10 to 15 million sperm/ml, moderate oligospermia is diagnosed when the sperm count is 5 to 10 million sperm/ml, and severe oligospermia is diagnosed when the sperm count is less than 5 million sperm/ml.

Causes of Oligospermia (Low Sperm Count):

Oligospermia can be caused by testicular or non-testicular infections, late-life testicular problems, and idiopathic or hereditary abnormalities.

Non-testicular reasons include a lack of proper testicular support, general habits, drugs, alcohol, smoking, a lack of vitamins and hormones, or the testicles being physically injured during activities such as horseback riding and cycling. Non-testicular reasons include hypogonadism (a lack of sex hormones) caused by hormone therapy or other conditions.

Causes related to Testicles:

Although there is no hormone deficit in oligospermia individuals, a reduced sperm count owing to testicles may occur. These include sperm count reduction with age, Y chromosome genetic disorder, abnormal chromosome structure, USP 26 enzyme disorder, abnormal growth in any body tissue (neoplasm), reproductive (genital) system structural differences, varicocele, swelling in the testicular bag (hydrocele), previous mumps or malaria.

Causes occurring in the testicles later on:

These are conditions that have a detrimental impact on the male reproductive (genital) system following sperm production in the testicles and sperm functional quality in males due to ejaculation issues. Low sperm count can be caused by infections or prostate issues, cystic fibrosis, or a blockage in the ejaculation channel.

Idiopathic (having no known reason) Oligospermia

The condition of this group of oligospermia patients is known as idiopathic in 30% of men, since low sperm count or poor sperm quality is characterized as idiophatic under clinical or laboratory criteria. A few reasons influencing this 30% include age, infectious infections (such as chlamydial infection), microdeletion syndrome, mitochondrial alterations, environmental pollutants, and growing hormonal changes.

In a 2013 research, it was shown that oligospermia and azoospermia disorders were substantially connected with being overweight or obese, but the explanation was still unknown because people who are slim also had similar diseases.

DNA damage-induced oligospermia

During meiosis, the breast cancer susceptibility gene 2 (BRCA2) repairs homologous recombination of damaged DNA. This gene's mutations have been linked to severe oligospermia.

Oligospermia (Low Sperm Count) Therapy

Because the reason or causes of oligospermia are unknown, the specialist physicians' beginning point is a healthy lifestyle and the process of correcting the person's identified missing difficulties.

It is considered that, in addition to typical professional advice such as a good diet, regular exercise, stopping smoking, avoiding poisonous drugs, and so on, herbal remedies may also be a cure for this ailment. Herbal therapies and testosterone boosters are favored. Stem cell therapy is another natural therapeutic option.

Therapy of Oligospermia (Low Sperm Count) with Stem Cells

Before undergoing stem cell therapy for oligospermia, semen analysis, genetic karyotype analysis, and a testicular biopsy sample may be necessary to establish whether the findings may be reached using simpler means.

Therapy alternatives are assessed based on these findings. If the patient is judged to be a good candidate for stem cell therapy, he or she will be given the necessary blood tests and can then begin therapy.

Therapy Process

Stem cells have the power to transform into the cells they have come into contact with. As a result, they are used to treat oligospermia. Even if there are few sperm-forming cells, they contact these cells, increasing their number and ensuring sperm production.

Stem cells collected from the patient are supplied to individuals who do not have any genetic abnormalities.

Patients with hereditary oligospermia are treated by injecting them with stem cells that do not contain the disease. It is chosen which sort of stem cells to deliver at the completion of all testing. However, fresh sperm generation takes at least 72 days after the complete testis structure has healed. As a result, sperm production is likely to begin within 6 months to a year of therapy.

'Spermatogenesis' refers to the process of combining all stages of sperm production and development. Spermatogenesis is the process through which a sperm cell progresses from the stem cell stage to the mature sperm stage. This process takes between 65 and 75 days to finish. Understanding the stages of the spermatogenesis process and how each step influences the process is critical in determining how the therapy should be carried out.

Method of Administration:

The amount of cells to be supplied is decided by the patient's age and weight. Mesenchymal stem cells (produced from the patient's own adipose tissue or bone marrow) or fetal stem cells are used in therapy. The therapy of the patient is determined by the patient's condition. It can be done in three 45-day increments or three consecutive days. The therapy regimen is carefully changed based on the patient's condition, and each patient may receive a different procedure.

Success Rates in the Therapy of Oligospermia with Stem Cells

The success rate is at least 95% if there are even a small number of viable cells in the sperm-generating cells inside the testis. After sperm production, the procedure can be repeated after a year to enhance the quantity of sperm. The duration of sperm formation evaluation is no earlier than six months following therapy.

Frequently Asked Questions

Can stem cell therapy be applied to every patient with oligospermia?

Stem cell therapy can be used if the patient is not getting cancer therapy, does not utilize cell killer medicines, and possesses viable sperm cells, even in modest amounts.