Parkinson's Therapy with Stem Cells in Turkey

Parkinson's disease development can be delayed, reversed, or even stopped entirely using stem cell therapy. The success rate of the therapy is related to the patient's age, disease duration, and condition. The patient's quality of life improves dramatically as a result of the muscular improvement. The use of stem cells to treat Parkinson's disease is acknowledged as a novel approach that scientists are exploring.

●    When stem cells come into contact with injured brain cells, they have the capacity to transform into brain cells. As a result, stem cells are being employed to treat Parkinson's disease.

●    The amount of cells to be supplied is decided by the patient's age and weight. The therapy is delivered in three 45-day periods or three consecutive days.

●    The therapy regimen is carefully changed based on the patient's state, and each patient receives a unique program.

●    ​​​​​​​The given stem cells are tiny enough to pass through brain cells. As a result, early diagnosis enhances the therapy's success percentage dramatically.

Previous research found that stem cell therapy had a high percentage of good outcomes. In 74% of the patients, this therapy considerably slowed disease development and helped to resolve the current critical illness.

What is Parkinson's Disease?

Parkinson's disease is a slowly progressing brain disorder that primarily affects males over the age of 40 and is characterized by the loss of brain cells. Parkinson's disease is caused by a shortage of dopamine production and release (the chemical that allows neurons in the brain to communicate). When 60% to 80% of dopamine-producing cells die, an appropriate quantity of dopamine cannot be generated, and Parkinson's disease symptoms appear. It is not lethal and does not induce a stroke.

This brain malfunction causes us to tremor at rest and delays our typical motions. The condition persists owing to hereditary transmission and male prevalence.Parkinson's disease symptoms will worsen with time.

What are the symptoms of Parkinson's disease?

It is believed that symptoms such as loss or diminished sense of smell, sleep difficulties, constipation, tremor, and slowness of movements occur years before the disease's motor symptoms. Parkinson's disease manifests itself first in the enteric nervous system, lower brain stem, and sense of smell tracts. Parkinson's disease travels from these areas to the brain's top regions, namely the substantia nigra and the cortex.

The researchers are looking for ways to reduce disease development by detecting non-motor signs as early as feasible in the illness's course.

Parkinson's disease strikes at an average age of 60, and it presents differently in each patient and with distinct symptoms. Symptoms can emerge at any age, however it is uncommon in those under the age of 30. Genetic reasons are prominent in the form that appears at a young age. The disease's symptoms might differ from person to person, and hence the course of symptoms differs.

Parkinson's disease symptoms are classified as movement-related or non-movement-related (motor or non-motor).

Motor Symptoms:

Tremor, slowing motion (bradykinesia) and contraction of the muscles, inability to move (akinesia), contraction of limbs, inconsistent walking and hump.

Non-Motor Symptoms:

Sleep difficulties, constipation, loss of smell, depression, sexual dysfunction, and anxiety are some of the symptoms.

One of the initial signs is generally a slowing of one's motions with one hand, and sliding of the arm when walking may also occur. Shoulder ache may accompany this.

●    ​​​​​​​Many people have tremors, which are initially minor and most evident when they are resting. Tremors are most commonly felt in the hands, although they can also affect the arms and legs. However, 15% of Parkinson's sufferers never develop tremor during their illness.

●    ​​​​​​​Symptoms often appear on one side of the body. If the dominant side of the body is injured, the symptoms are most obvious when performing typical tasks like writing. 

●    ​​​​​​​People with tremor whose symptoms affect the dominant area of the body benefit more from early diagnosis and therapy by contacting a doctor.

●    ​​​​​​​People in the early stages of Parkinson's disease may also have balance issues, such as losing balance when standing or having difficulties turning back or making rapid movements. Parkinson's sufferers typically exhibit less facial expression and speak more slowly. Non-motor symptoms such as sleep difficulties, depression, and anxiety can frequently precede motor symptoms.

Causes of Parkinson's

A British doctor named James Parkinson first characterized Parkinson's disease in 1817. The majority of patients are in the non-familial "sporadic group," which frequently begins in later life. If diagnosed early, the condition is more likely to be hereditary.

It is recognized for gradual progressive cell loss and degeneration in the brain stem region's "substansiya nigra" subgroup of cells. The reason of these cells' loss and degeneration is unknown.

The black nucleus's cells create a chemical known as "dopamine." Dopamine guarantees that our motions are launched, resulting in smooth and balanced movements. Dopamine deficit in Parkinson's disease produces the illness's symptoms.

Parkinson's Disease Therapy 

Therapy for Parkinson's disease is mostly drug-based. The idea is to replace dopamine, which is poorly synthesized in the brain. Surgical therapy is not appropriate for all patients. Some symptoms that do not respond satisfactorily to therapy may warrant surgical intervention. Because some parts of the brain work excessively in Parkinson's disease due to dopamine insufficiency, surgical techniques allow these regions to work less. Two approaches are employed for this purpose: "Ablation (destructive) surgery" and "Battery implanting surgery (Deep brain stimulation)". Walking, swimming, or other sports activities may also be prescribed to decrease the progression of the condition and give comfort.

Parkinson's Therapy with Stem Cells

Because stem cells have the ability to transform into brain cells when they come into contact with injured brain cells, they are employed in the therapy of Parkinson's disease.

They also cure injured nerves and muscles in a similar manner. In this approach, they may be able to reduce the growth of the disease, stop it totally, and cause it to regress. The therapy's success rate is proportional to the patient's age, disease duration, and condition. If the illness has advanced significantly, therapy may need to be repeated.

The given stem cells are tiny enough to pass through brain cells. As a result, early diagnosis enhances the therapy's success percentage dramatically. The therapy is delivered in three 45-day periods or three consecutive days.

The amount of cells provided is regulated by the patient's age and weight, and therapy is performed with mesenchymal stem cells (taken from the patient's own adipose tissue or bone marrow) or fetal stem cells. The choice is based on the patient's condition. Previous research found that stem cell therapy had a high percentage of good outcomes. In 74% of patients, this medication greatly slowed disease development and helped to alleviate the advanced severe illness.

FREQUENTLY ASKED QUESTIONS

Who is most likely to have PARKINSON'S?

It commonly begins in people over the age of 60. Only a small percentage of Parkinson's patients develop the condition between the ages of 20 and 40. In younger individuals, genetic reasons should be examined. Men are more likely to be affected than women. The disease's prevalence, which is found all throughout the world and in all socioeconomic levels, varies by country.

Is PARKINSON a Genetic (Hereditary) disease?

Parkinson's disease is known as "Young Onset Parkinson's Disease" (YOPD) among persons under the age of 40. Genetics has a huge influence on this group of patients. As a result, it is correct to suggest that members of a YOPD family are at genetic risk.

What causes tremor in PARKINSON Disease?

Dopamine guarantees that our motions are launched, fluid, and harmonized. Dopamine insufficiency develops in Parkinson's patients as a result of a reduction in the cells in the black nucleus, resulting in disease symptoms.

How is Parkinson's diagnosed?